The album features guest appearances from several hip hop and R&B acts, namely Mos Def, Nicole Wray, Pharoahe Monch, Ludacris, Billy Danze of M.O.P., Q-Tip of A Tribe Called Quest, Jim Jones and NOE of ByrdGang, as well as Raekwon, RZA and Ol' Dirty Bastard of Wu-Tang Clan.

[1] After Damon Dash began listening to Ohio-based rock duo the Black Keys, which he says quickly became his favorite band, he reached out to the musicians to meet in person.

Included in the project are vocals from deceased rapper and former Roc-A-Fella Records artist Ol' Dirty Bastard, tapes which were signed over to his brief Roc4Life venture under Def Jam, with the intention of an eventual album release.

Nick Neyland of BBC music stated in his review "this is a surprisingly compelling and welcome rejoining of the rap and rock worlds that successfully captures the off-the-cuff nature of the recording sessions.

[16] In an interview with Atlanta radio station 92.9 Dave FM later that month, Black Keys drummer Patrick Carney said, "Blakroc 2 is not coming out soon... there are no plans for that.