The original music video for the song was a low-budget clip starring a puppet dinosaur named Frank who is standing beside a plant.

He later made a similar teaser video for "Next Girl", where Frank interacts with bikini-clad models.

Auerbach sits next to Carney on a bench while their fictional sons play with toy trucks.

Auerbach's son looks up on the playground to see a little girl, after which he starts to lip sync to the song.

The Black Keys Additional musicians Technical personnel On the week ending November 6, 2010, "Tighten Up" debuted at number 93 on the Billboard Hot 100.

"Tighten Up" has been licensed to appear in EA Sports game FIFA 11, the musical video games Rocksmith, Rock Band 3 (as downloadable content for both) and Guitar Hero Live, the TV series Gossip Girl, a Subaru commercial, a Molson commercial, and the films I Am Number Four, Bad Teacher, and Spring Breakers.

In 2015, a cover by Justin Young was used in the sci-fi TV series The Expanse, in the first episode of season 1, "Dulcinea".