An infection in the past caused the automated systems to spiral out of control, resulting in a multi-leveled city structure that grows indefinitely in all directions.

A girl named Zuru goes on a journey to find food with a group of friends, only to inadvertently trigger a Watchtower which spawns robotic exterminators.

Killy reveals that he is on a quest to find someone with the Net Terminal Gene, which would allow accessing the Netsphere and regaining control of the city.

He leaves for an area below the village named the Rotting Shrine, and followed by Zuru and Tae, he finds the spoilt machine-corpse of Cibo, a former scientist from before the disaster.

Heeding her words, a group of Electro-Fishers including Tae and Zuru travel to the automated factory in search of more rations.

She is forbidden to do so, but is instead allowed access to the City's map, revealing an abandoned level safe from Safeguard control where the villagers can migrate to.

[4] The film was directed by Hiroyuki Seshita and written by Tsutomu Nihei and Sadayuki Murai, with animation by Polygon Pictures and character designs by Yuki Moriyama.

On October 5, 2017, Viz Media announced at their New York Comic Con panel that they had licensed the home video rights to Blame!

Denki Ryōshi Kiki Kaisō Dasshutsu Sakusen, illustrated by Kotaro Sekine, was serialized in Kodansha's Monthly Shōnen Sirius from April 26 to October 26, 2017,[7][8][9] and collected into one volume, released on February 9, 2018.

[11] Toussaint Egan of Paste praised the adaptation for being both faithful and opening it to wider appeal, concluding that it is "one of the most conceptually entertaining anime films of late".