The eastern part of the municipal territory lies in the Moravian Karst Protected Landscape Area.

It was the site of dispute between Jindřich Zdík, the bishop of Olomouc, and Prince Wratislaus of Brno regarding the rights to construct a church in the village.

In the late 16th century during the rule of the Žalkovský of Žalkovice family, Blansko was promoted to a market town.

In the first half of the 19th century, the ironworks prospered and developed and the expansion of the production of artistic cast iron occurred.

[3] The largest industrial employers based in the town are Pyrotek CZ (aluminum processor), ČKD Blansko (manufacturing of hydro machines, heavy-duty machining tools and mechanical engineering metallurgy, founded in 1950),[6] and a branch of Synthon (producer of generic drugs).

The longest tradition has the still operating company Metra Blansko, manufacturer of electric measurement devices, which was founded in 1911.

The club participated in the 2020–21 season of the Czech National Football League, but was immediately relegated.

[10] The wooden Church of Saint Paraskieva was built in Carpathian Ruthenia in 1601–1641 and brought to Blansko in 1936.

[12] The town hall from 1885 replaced an old wooden structure with a tower which originated from the 16th century.