The first reboot, Blaster Master: Overdrive, was released in 2010 and intended to "rebuild the Sunsoft brand in North America", but it received mediocre reception from critics and did not see a follow-up.

After another hiatus, the series was rebooted again by developer Inti Creates with the 2017 video game Blaster Master Zero, which retained an 8-bit style of graphics alongside similar gameplay and level design to the original, serving as a sort of reimagining of the title.

The premise of the series revolves around Jason, a young man who uses a special tank known as SOFIA to explore areas and battle radioactive mutants.

[2] Blaster Master Zero 3 was announced by Inti Creates on March 4, 2021, and then released on July 29, 2021, for Nintendo Switch, PlayStation 4, and Windows for both Steam and Epic Games Store.

[3] A short-lived comic loosely based on the premise of the original Blaster Master ran in the Sunsoft Game Times News newsletter in 1989.