For her first mission, Rayne is deployed to the town of Mortton, Louisiana, to investigate reports of a plague that is transforming local residents into zombie-like mutants.

In Mortton, Rayne finds the town infested by spider-like monsters called Maraisreq, one of which devours and apparently kills Mynce.

Before she can recover from the shock, Rayne is attacked by a man in a Nazi uniform who forcibly removes the rib from her body and leaves her for dead, although she survives.

Five years later, in 1938, Brimstone sends Rayne to Argentina to perform reconnaissance at a mining facility where the Nazis are rumored to be searching for a mystical relic of great power.

Brimstone provides Rayne with a target list of high-ranking Nazi officers to assassinate, one of whom she recognizes as the man who attacked her in Louisiana: Jürgen Wulf, leader of the Gegengeist Gruppe (G.G.G.

As Rayne descends into the mine, she discovers that the facility has been overrun by "Daemites," demonic parasites that take humans as hosts and serve to guard Beliar's skull.

Deep within the mine, Rayne locates the crystal skull containing Beliar's eye, the true relic, which implants itself into her head, enhancing her vision.

Unbeknownst to the Nazis, Castle Gaustadt is home to a clan of ancient vampires that, after centuries in isolation, have evolved into bestial monsters.