[1] The practice was originally developed in the United States,[1] but most recent research on it has been conducted in Germany (by UV lamps) and in Russia (in all variants).
[6] Furthermore, it has been claimed that ultraviolet irradiation of blood kills bacteria by DNA damage and also activation of the immune system.
In 1928, Dr. Emmet Knott and a medical student named Lester Edblom received a United States patent for a "Means for Treating Blood-Stream Infection" that incorporated a rudimentary ultraviolet bulb, vacuum extraction system and a cuvette.
George P Miley at the Hahnemann Hospital in Philadelphia, Pennsylvania, published a series of articles on the use of the procedure in the treatment of thrombophlebitis, staphylococcal sepsis, peritonitis, botulism, poliomyelitis, non-healing wounds, and asthma.
One of the best known and most comprehensive set of studies was published in 1947 by Dr. George Miley and Dr. Jens A Christensen (from the Blood Irradiation Clinic of the Hahnemann Medical College and Hospital of Philadelphia, Pennsylvania).
Henry A Barrett at the Willard Parker Hospital in New York City, in 1940 reported on 110 cases including a number of infections.
[10] Observational evidence suggests that photopheresis might be effective in the treatment of graft-versus-host disease,[11] though controlled trials are needed to support this use.
It is shown that ILBI improves blood flow and its transport activities, therefore, tissue tropism, has a positive effect on the immune system and cell metabolism.
[2] Transcutaneous therapy applies laser light on unbroken skin in areas with large numbers of blood vessels (such as the forearm).