By 1927, after acquiring all the remaining portions along it, Bloomingdale's controlled 100 percent of the block, expanding the store's size to 84,000 square feet (later nearly quadrupled via newly added floor space).

[5] Like most publicly traded companies, Bloomingdale's faced severe financial problems following the Black Tuesday stock market crash in 1929, and it merged with the newly created Federated Department Stores in early 1930, which helped it survive the Great Depression.

The store's commitment to offering a wide range of high-quality merchandise and its role in shaping fashion trends laid the foundation for its continued growth and legacy in the decades to come.

After concluding that using pre-existing buildings could have been a better fit with its tried-and-true floor layouts, the company debuted its first custom-built store in 1949, located in the Fresh Meadows neighborhood across the East River in Queens.

[5] During the 1960s, Bloomingdale's shifted its merchandise mix to incorporate haute couture fashions imported from Paris and home furnishings from Italy.

It also launched its first single designer-specific department in 1969, for Halston, one that was quickly followed later that year by a dedicated Polo Ralph Lauren boutique in its men's store.

[5] In 1976, Bloomingdale's launched its first full-line department store outside of the New York City area in Tysons, Virginia, a suburb of Washington, D.C..[6] The First Lady at the time, Betty Ford, attended its opening as its guest of honor.

[7] In 1988, Canadian real estate developer Robert Campeau launched a hostile takeover attempt of the company, successfully acquiring it for $6.6 billion: it was the largest non-oil corporate merger ever at the time.

[5] Bloomingdale's faced continued economic challenges in the early 1990s, resulting in the closures of its Dallas, Fresh Meadows, and Stamford, Connecticut locations.

In 2006, Bloomingdale's opened its largest store save its Manhattan flagship in San Francisco's Union Square, 330,000 sq ft (31,000 m2) in area.

One was intended to be a three-level 82,000-square-foot (7,600 m2) anchor store at The Shops at Georgetown Park in Washington, D.C.,[10] but the plan collapsed after the mall's parent company declared bankruptcy.

[16] As part of an initiative to better establish its New York flagship store as a "retail destination," designed to allure shoppers who primarily purchase department store goods online, Bloomingdale's introduced new departments and offerings throughout the decade, including a branch of Magnolia Bakery and a boutique for Sarah Jessica Parker's SJC Collection shoe line.

In 2018 and 2019, Bloomingdale's remodeled nearly 200,000 square feet inside the store, wholly revamping its denim, cosmetics, shoes, and women's contemporary clothing departments.

On September 9, 2022, Bloomingdale's celebrated its 150th anniversary, featuring a variety of special events and unique merchandise offerings through the end of the year at its Manhattan flagship location.