Major tenants include Bayhealth Medical Center, the State of Delaware, the U.S. Social Security Administration, and an outpatient clinic operated by the U.S. Department of Veterans Affairs.

[4][8] Popular early stores included Hess Apparel, Benjamins, Dannemann's Fabrics, Thom McAn, and Thrift Drug.

Russell Stover Candies (later Walt's Dairy Bar), Bavarian Pretzel, and Woolworth's Harvest House Restaurant formed a cluster of eateries adjacent to the cinema.

The mall's design featured terrazzo floors, rock walls, tile mosaics,[10] multiple fountains, and a waterfall under the main staircase.

[11] A four-sided blue hen clock hung from the ceiling in center court, playing a crowing sound on the hour.

[19] New signage with blue neon accents was added to the center court,[20] and the hanging clock was removed on August 27, 1987.

A handful of national chains, including GNC and Radio Shack, remained at the mall into its final years.

[7] Woolworth closed their Blue Hen Mall store after the 1993 holiday season[23] as part of a larger corporate restructuring.

[24] Roses closed their Blue Hen Mall location on March 19, 1994, due to the chain entering Chapter 11 bankruptcy.

[25] Dover Cinema, a single-screen movie theater, opened at the mall in March of 1969 with a special showing of Gone with the Wind.

Parking space is available virtually at the door and the box office is entirely indoors, both of which help eliminate the problems of wind and weather", wrote critic Otto Dekom in an article about the theater's opening for the Wilmington, DE Morning News.

[34] In August of 1989, a woman was sexually assaulted, beaten, and robbed by a man hiding in the public restroom at the Woolworth's restaurant.

[35] Another sexual assault was reported in August of 1992, when a woman was grabbed in the Roses parking lot and forced into a car.

[15] Pettinaro later completed an exterior renovation of the building, which added new office entrances, windows, landscaping, and signage, in addition to repairing original stucco finishes.

After a major interior renovation, Bayhealth relocated their administrative offices, information technology, orthopedics and sports medicine departments to the new facility.

[41] In January of 2022, Bayhealth announced that it had completed a $17 million acquisition of both original end anchor spaces (formerly JCPenney & Woolco/Roses).

[42] The U.S. Department of Veterans Affairs also operates an outpatient clinic at Blue Hen, offering "general medical care, including primary care, addiction and substance abuse treatment, mental health, laboratory services, PTSD treatment, women's health, and more.