It is situated at the intersection Germantown Pike and Hickory Road, near the Mid-County Interchange between the Pennsylvania Turnpike (I-276) and the Northeast Extension/Blue Route (I-476).

[7] A redevelopment of over $100 million in 2007-2009 added new restaurants and an open-air "Lifestyle" wing featuring LOFT, Coldwater Creek (since closed), Jos.

During the redevelopment, in April 2009, a two-story chain arcade called Krazy City was constructed in the mall's interior, near Boscov's, taking up several store spaces.

IKEA later moved in early 2003 to its current site at 400 Alan Wood Road, off of Interstate 476 (the "Blue Route") in nearby Conshohocken.

In recent years, the interior of the Plymouth Meeting Mall has seen an increase in vacancies, with sales of $320 per square foot in the three months ended September 2015.

In late 2013, a casual Mexican chain restaurant opened in the second floor mall entrance wing next to Macy's and across from Dave & Busters, called Uncle Julio's.

In 2015, it was announced that a 33,000-square-foot (3,100 m2) Legoland Discovery Center would be constructed at the Plymouth Meeting Mall, replacing a portion of the food court.

[12] In August 2018, it was announced that Burlington, Dick's Sporting Goods, Michaels, and Edge Fitness would occupy the former Macy's space, with all tenants opening in October 2019.

[15] The mall is currently anchored by Boscov's, Burlington, Dick's Sporting Goods, Michaels, Edge Fitness, Whole Foods Market and an AMC Theatre.