The twelfth season of the American animated television series Bob's Burgers debuted on Fox on September 26, 2021, and ended on May 22, 2022.

Production of these episodes was minimally affected by lockdowns during the COVID-19 pandemic as some voice actors recorded parts from their homes in April 2020.

[3][4][5] In December 2021, it was reported that Jay Johnston had been "banned" from his recurring role as Jimmy Pesto due to his alleged participation in the January 6 United States Capitol attack.

This season aired on Fox on Sundays as part of its Animation Domination block along with The Simpsons, The Great North, Duncanville, and Family Guy.

Starting with this season, the series runs on Disney+'s Star segment in Canada, UK and Australia, where episodes premiere weekly on Wednesdays.