Smith, along with fellow comedians Jaffe Cohen and Danny McWilliams, formed the comedy troupe Funny Gay Males in 1988.
[7] The essays covered a wide range of subjects including his career in stand-up, his love of nature, and his experience with ALS.
In response to an August 2012 New York Times article on openly gay male stand-up comedians, Smith posted a comment stating he had ALS.
[9] The article also revealed that Smith assisted with the conceiving of fellow LGBTQ comedian Elvira Kurt's children, who with Kurt reside in Canada;[9] and that he was a direct descendant of Henry Smith of Pelham, an early settler of Canada's Niagara Region for whom the Henry of Pelham Winery is named.
[9] Bob Smith died on January 20, 2018, from Lou Gehrig's Disease in his Manhattan home at 59 years of age.