Unique among parvoviruses, the bocaparvoviruses contain a third open reading frame between non-structural and structural coding regions.
[9] All bocaparvoviruses encode a novel protein called NP1 that is not present in parvoviruses from other genera.
In Canine minute virus NP1 has been shown to be essential for an early step in viral replication and is also required for the read through of an internal polyadenylation site that is essential for expression of the capsid proteins.
The virus exits the host cell by nuclear pore export.
Canine minute virus, first isolated in 1967 and associated with disease in 1970, causes respiratory disease with breathing difficulty and enteritis with severe diarrhoea, spontaneous abortion of fetuses, and death of newborn puppies.
The incidence of bocavirus in patients with cancer is higher than that of healthy controls.
The structure of a virus-like particle composed only of VP2 protein was determined by cryogenic electron microscopy and image reconstruction.