This school serves the Maryland communities of Chesapeake City, Cecilton, Galena, Earleville and the parts of Elkton.

The final Chesapeake City and Cecilton High School graduation ceremonies took place during June 1958 and the first Bohemia Manor High School graduation ceremony occurred during June 1959.

In 1996, grades 6th through 8th were made to form Bohemia Manor Middle School.

In the 17th century, a surveyor named Augustine Herman made one of the first maps of Cecil County, where the school resides.

In the 18th century, a plantation called Bohemia Manor was located only a few miles from the school grounds.