Bolesatine is a glycoprotein isolated from the Rubroboletus satanas (Boletus satanas Lenz) mushroom which has a lectin function that is specific to the sugar binding site of D-galactose.
One tryptophan can be found in its primary sequence along with one disulfide bridge.
Bolesatine causes gastroenteritis in humans[2] and, at high enough concentrations, inhibits protein synthesis.
[5] Studies have shown that at low concentrations, protein kinases C (PKC) are activated in vitro and in vero cells, leading to an increase in DNA synthesis activity.
[6] Other than the accumulation of toxins in human liver and organs, Bolesatine poisoning causes agglutination in human red blood cells and platelets at threshold concentrations.