The Bolshoy Kub (Russian: Большой Куб) is a river in Perm Krai, Russia, a left tributary of the Veslyana, which in turn is a tributary of the Kama.

The river is 37 kilometres (23 mi) long.

The Bolshoy Kub flows into the Veslyana 121 kilometres (75 mi) from the larger river's mouth.

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