Park began her musical career in 2006 under YG Entertainment, featuring on singles released by label-mates Big Bang, Lexy, and Masta Wu.

After that, in May 2019, Park Bom released her new repackaged album re: Blue Rose, with the single "4:44" featuring Wheein from Mamamoo.

Whilst attending junior high school in the United States, she was diagnosed with attention-deficit hyperactivity disorder (ADHD).

[10][11] Park also collaborated with Lexy on "Baby Boy" from her third extended play Rush, and Red Roc on the single "Along My Way".

She has also appeared in a series of promotional music videos for Samsung Anycall of the same name, alongside Lee Hyori, G-Dragon, and Gummy.

The group achieved significant success with the number-one single "I Don't Care" from their first extended play, 2NE1, which won them the Song of the Year award at the 2009 Mnet Asian Music Awards, making them the first rookie group to win a daesang in the same year of debut.

The single was a success and achieved a perfect all-kill on Instiz, placing number one on seven local music charts.

[21] In a statement issued by YG Entertainment's Yang Hyun-suk, he spoke against the allegations of preferential treatment.

Yang further explained that Park sought out medical care from South Korean physicians and had undergone therapy for attention deficit hyperactivity disorder but proved to be not as effective as her treatment in the United States.

[19] In 2010, at the time of investigation, she had provided the prosecutor her medical records from her U.S. hospital confirming her diagnoses as well as ongoing treatment plan.

[22] That same year, Park joined the cast of SBS's Roommate, a reality show which features eleven celebrities living together in a share house.

On April 30, 2017, she announced through social media that she is now under YG Entertainment's subsidiary, The Black Label, and is preparing to release a solo album.

[32] The following day, it was reported that she would be making her first small screen appearance in four years through YG Future Strategy Office, which stars former labelmate Seungri.

[43] She released three singles throughout her run in the competition: covers of "Hann (Alone)" by fellow competitor (G)I-dle and "Eyes, Nose, Lips" by former labelmate Taeyang,[44][45] and an original song titled "Wanna Go Back" ,[46] wherein the former features vocals from Cheetah.

[49] She released a standalone single titled "Do Re MI Fa Sol", which features vocals from Changmo, on March 31, 2021.

[51] On November 2, 2022, D-Nation Entertainment announced that the release of "Remembered" would be postponed to a new later date due to the aftermath of the Seoul Halloween crowd crush.

During 2NE1's concert at the Philippines' Mall of Asia Arena, Park was unable to complete her performance due to health issues.