It has three platform tracks and is located on the Left Rhine line south of Bonn Hauptbahnhof.

[1] On 21 January 1856, the section of the Left Rhine line between Bonn and Rolandseck was opened to traffic.

A slightly recessed platform in the station served from 1949 as the location for travel and receptions of the American High Commissioner John J. McCloy and his successors to 1955 and the subsequent U.S. ambassadors.

After 1963, the permanent stationing of trains at Bonn-Mehlem station for the American Embassy was terminated for financial reasons, but when required railbuses of classes VT 08-8 and VT 33.8 came from their base in Heidelberg, then the most important base for American troops in Germany.

Once a year, possibly more often, a special train carried the U.S. ambassador via the Brunswick–Magdeburg railway through Helmstedt on the established transit route to Berlin-Lichterfelde West.