"Molecular bookmarks" are the factors that allow transcription to resume in an orderly fashion in newborn cells following mitosis (when the book is re-opened).
[3] More recently genome accessibility during interphase and mitosis has been directly compared on a genome-wide scale.
[4] While gene promoters tend to be better preserved than distal regulatory elements, substantial variation exists at individual sites.
[5][6][7] Patterns of DNA methylation are generally unchanged and also have the potential to function as bookmarks.
Notable transcription factors implicated in mitotic bookmarking include: