[3] The film tells three stories, two of which are loose adaptations from the titular horror fiction anthology: "The Book of Blood" ("Miles") and "On Jerusalem Street" (a postscript) ("Bennett").

Jenna Branson is a college student suffering from a mental illness that makes the smallest of noises overwhelming for her.

She begins to suspect that someone is following her and takes refuge at a bed and breakfast run by older couple Ellie and Sam Austin.

She is horrified when she discovers that the couple have been paralysing their guests, sewing their eyes shut, removing their tongues and ears, and hiding them within the house.

Mary Floresky is approached by a psychic named Simon McNeal, who claims that he is communicating with her dead son Miles.

Later a devastated Mary sees her son's ghost and watches as a message entreats her to repeat the experiment with Simon.

When he is unable to produce what is owed, the seller attempts to save his life by telling Bennett of the "Book of Blood", a rare tome worth a million dollars, that's located in an abandoned town.

Together with Steve, Bennett travels to the abandoned town where both men experience inexplicable and supernatural phenomena.