From their inaugural season of 2001 through 2003, the Cannons played their home games at Cawley Memorial Stadium in Lowell, Massachusetts.

Head coach Bill Daye stepped down a month after winning the Steinfeld Cup, citing he wanted to spend more time with his family.

John Tucker left the Cannons after the 2015 season to become the first head coach and general manager of the expansion team Atlanta Blaze.

On October 8, 2015, Sean Quirk was announced as the sixth head coach in franchise history.

On December 20, 2016, it was announced that John Tucker would be returning to the Cannons as the team's offensive coordinator in 2017.

At 3–6, the Cannons traded away captain Will Manny and Joe LoCascio to the New York Lizards for Dave Lawson and Chris LaPierre on June 27.

Following the 2018 season, Paul Rabil launched the Premier Lacrosse League, baiting over 140 MLL players to migrate over.

However, the Cannons maintained more of their roster than other teams like the Dallas Rattlers or Rabil's New York Lizards.

[10] Taking this to their advantage, the Cannons posted a 9–7 record in 2019, good enough for the third of four postseason seeds and gave Boston its first playoff berth since 2015.

The Cannons got off to a hot start and led by as many as six goals, but ultimately fell, 17–15, ending their season.

[13] Newcomer attackman Bryce Wasserman, who played for the Dallas Rattlers the season before, was named league MVP for 2020.

Small tweaks to the former Boston Cannons branding resulted in a PLL crest and logo reveal on January 12, 2021.

[15] The Cannons played their first game of the 2021 season on June 4 at Gillette Stadium in Foxborough, Massachusetts, falling to the Redwoods Lacrosse Club, 12–11.