The fungus has no known asexual state, and unlike many related fungi, is intolerant of high heat exhibiting limited growth when incubated at temperatures over 35 °C.

[2] In 2016 X. W. Wang et al. re-examined a set of cultures of Chaetomium-like fungi using phylogenetic analysis of the DNA directed RNA polymerase II subunit gene sequence.

[9] Along with other close related species of Chaetomium such as C. globosum and C. funicola, B. murorum can degrade cellulose material in paper,[6][10] as it expresses cellulase,[10] xylanase, peroxidase, and laccase activities.

[3] The asci grow in bundles, usually club-shaped, and usually form eight irregularly arranged, 12–16.5 x 7–8.5 μm ball-shaped ascospores, with apical germ pores.

[4] Symptoms include lesion, pus, thickening of skin, and chromoblastomycosis-like, muriform bodies-less tumorous mass, which makes it easily to be misdiagnosed.

[9] Botryotrichum murorum produces the secondary metabolites Chaetoxanthone C and D,[14] which cause selective cytotoxicity towards some human protozoan parasitic pathogens, such as Trypanosoma cruzi and Plasmodium falciparum.

[15] The chemical pigment isocochliodinol and neocochliodinol, unique to B. murorum and its close related fungus C. amygdalisporum,[16][17] has shown cytotoxic activity towards HeLa cells.