The show centers around a boy, a girl, a dog, a cat, a mouse, and a piece of cheese, all respectively named after what they are, who live together.

[7] Boy Girl Dog Cat Mouse Cheese was nominated in the 'Best Animated Kids Series 6+' and 'Best Music' categories at the Irish Animation Awards in 2021, with Baljeet Rai and Henry Gifford nominated for the 'Best Writer' award for the episode Neighborhood Watchdog.

[8] Boy Girl Dog Cat Mouse Cheese is produced by Cloudco Entertainment in the United States, WatchNext Media in France, and Kavaleer Productions in Ireland.

Sophie Yates from Bulldog Licensing explained that Boy Girl Dog Cat Mouse Cheese brings together today's kids and tweens, and tackles the topic of blended families with humor and fun.

On February 15, 2021, this series was broadcast for the first time in Germany on the channels Super RTL and TOGGO plus.