It is native to the southeastern region of the United States, ranging from West Virginia to Alabama and Georgia.

[3] It grows in wet woodlands, on the edges of ponds and lakes, or in other moist areas, flowering in the summer.

It has both basal and cauline leaves, with petioles three to eighteen centimeters long.

Leaves are generally reniform, but can be orbiculate to cordate with three to seven lobes.

[2] According to the Southern Appalachian Species Viability Project, Boykinia aconitifolia is at high risk due to sedimentation and other pollutants.