When Di Meglio turned 15 years old, he decided to accept offers by the Italian Freesoul Racing Team on Aprilia to debut in the 125cc world championship in 2003.

Although he managed to score points, including 13th place at Catalunya, it was a difficult season for him, crashing often and not achieving good results.

Di Meglio was their official rider on board on a factory Honda RS125RW along with Fabrizio Lai but it was under the Kopron Racing World name.

He performed heroically at the French Grand Prix by fighting for a podium position, finishing fourth and making his home fans happy and entertained.

He also finished a credible fourth place in the hot Qatar Grand Prix ahead of future 125cc champion Thomas Lüthi.

The high point of the season for the Frenchman was his controversial win at the Turkish Grand Prix, when Mika Kallio crashed and race leader Luthi had run wide to avoid him.

He joined the Fédération Française de Motocyclisme's world championship team run by Alain Bronec for 2006.

His campaign started slowly within Qatar finishing in fourth, beaten to the podium at the line by Stefan Bradl.

In Spain and Portugal, Di Meglio picked up minor points and trailed title contender Simone Corsi, but starting in China, Corsi's pace started to slip away including a crash from a minor incident with Lorenzo Zanetti and reigning world champion Gábor Talmácsi struggling that allow Di Meglio to take full advantage.

A win in the shortened French Grand Prix started a consistent run lasting until at San Marino where he crashed out while fighting for third place with Corsi.

Despite his good results at those rounds, he failed to be competitive again until Australia where he finished in sixth place, having started on the front row.

TSR Honda France, replacing compatriot Alan Techer to partner Joshua Hook and Freddy Foray.

In late 2018, Di Meglio was confirmed to be rejoining the Grand Prix paddock as part of the inaugural MotoE season, racing for Marc VDS.

[5] He achieved a third-place podium in the German opener, followed by a grand slam in Austria (pole, win, and fastest lap), but subsequent retirements and poor finishes relegated him to just 6th position at the conclusion of the season.