He has been involved in numerous experiments at Brookhaven National Laboratory, Stanford Linear Accelerator Center, Fermilab and CERN.

[7] At Duke, Johns Hopkins, Fermilab and the University of Virginia, Cox participated in a number of high-energy physics experiments on fundamental particles of nature such as fermions, quarks, leptons and bosons that constitute the atoms.

[8] After joining Fermilab, Cox served as scientific spokesman for a series of high-energy experiments that studied the interactions of quarks and gluons by measuring the production of direct photons and lepton pairs.

[10] After E537, Cox served as spokesperson for the E705 experiment focused on studying the production of direct photons and charmonium states by antiproton, proton and π± beams.

[11] In the late 1980s, after taking a position as professor at the University of Virginia to build a Particle Physics experiment group, Cox initiated an effort to design a detector that would measure the CP violating effects in the B meson system at the Superconducting Supercollider (SSC) in Texas.

After the demise of the SSC, Cox refocused his research on CP violation in the neutral kaon system at Fermi National Accerator Laboratory in the U.S.

This experiment made the first statistically significant observation of “direct” CP violation determined by the measurement of a non-zero Re(ɳ’/ɳ),.

Cox's group at University of Virginia also made significant contributions to the discovery of a large CP violation effect in KL-> π +π - e + e - .

He was named the U.S. manager of the PbW crystal photon calorimeter, the part of the CMS detector that was most instrumental in the early detection of the Higgs particle.