Bradley E. Bernstein is a biologist and Professor of Cell Biology at Harvard Medical School.

Bernstein completed his residency in clinical pathology at Brigham and Women's Hospital, and his post-doctoral research in Stuart Schreiber’s lab at Harvard Chemistry.

[2] Bernstein joined the faculty at Massachusetts General Hospital and Harvard Medical School in 2005.

The lab uses high-throughput genomic technologies to study how chromatin controls gene activity in different contexts.

Bernstein's major contributions include ChIP-seq technology, now the standard for mapping chromatin and protein-DNA interactions in mammalian cells,[3] the characterization of bivalent chromatin[2] that poises developmental genes for alternate fates in development, and the identification of epigenetic defects that cause brain tumors and treatment failures.