The brain tissue will undergo liquefactive necrosis, and a rim of gliosis will form around the damaged area.
These cells extend processes, and form a delicate rim of gliosis around the margin of damage.
The empty space left by brain tissue fills up with cerebrospinal fluid.
After severe brain injury, improvement in function related to neuroplasticity is unlikely to occur without help from health professionals skilled in rehabilitation.
[1][2] A study done in Tel Aviv University showed severe brain damage can be reversed through oxygen rich air.