Pacitto started his acting career as a 4-year-old child, at the Clesis in Rome, and later entered the theatrical school by actor and playwright Thomas Otto Zinzi, with whom he still works today.

In 2006 he played the role of baby Jesus in the TV series The Holy Family (La sacra famiglia), co-starring Ana Caterina Morariu (Mary) and Alessandro Gassmann (Joseph).

(2011) by Monica Vullo, with Claudio Amendola and Serena Autieri, and in the two-episode film Walter Chiari – Fino all'ultima risata (2012) by Enzo Monteleone, with Alessio Boni and Bianca Guaccero, where he played the role of 15-year-old Simone Annichiarico.

Since the following year he's starring as Vale in highly rated TV drama Braccialetti rossi, also broadcast by Rai 1.

In 2015 he was in Jovanotti's L'estate addosso music video and in the homonymous film by Gabriele Muccino, released in September 2016.