He was selected by the Giants in the fourth round of the 2005 NFL draft, and won two Super Bowl rings with the team, both against the New England Patriots.

Jacobs was taller and heavier than the average NFL running back, standing at 6 feet 4 inches (1.93 m) and weighing 264 pounds (120 kg).

In his senior year, he received accolades such as USA Today All-America, Orlando Sentinel All-Southern, Prep Star All-Region and Louisiana Class 4A Most Valuable Offensive Player.

[3] In 2001, his freshman year at Coffeyville, he ran for 1,349 yards and 17 touchdowns and gained Kansas Jayhawk Conference All-Conference honorable mention.

[5] He once again garnered the Team MVP trophy and was also named the recipient of the Reb Russell Memorial Football Scholarship Award.

[7] Jacobs continued his college career at Auburn University, along with first-round draft picks Carnell Williams, Ronnie Brown, and Jason Campbell.

He led the team with 150 carries for 992 yards (6.6 avg) and 19 touchdowns, one less than the school's all-time leader, Muhammad Abdulqaadir, who, like Jacobs, also played at Coffeyville Community College.

He injured his knee in the first game of the season against the Dallas Cowboys, but returned four weeks later against the New York Jets to rush for 100 yards and a touchdown.

[15] He returned to play all of the preseason, but missed two games in the regular season due to recurring difficulty with his knee.

He is also nicknamed Juggernaut because of his ability to break multiple tackles and the difficulty in bringing him down due to his impressive size for a running back.

[23] He missed the first two months of the season after suffering a knee injury during training camp, and saw limited playing time once he returned.

[24] The 49ers suspended him for the final three games of the same season following a series of posts by Jacobs on social media sites addressing his lack of playing time, including one which said he was "on this team rotting away.

[28] On May 27, 2021, Jacobs announced on Twitter that he would be attempting a return to the NFL as a defensive end, stating "Just give me one chance thats all!!

[30] On October 19, 2012, Jacobs appeared, with Pro NRG founder Tania Patruno, to pitch the fledgling company's protein supplement/energy drink and hopefully score the venture some investment capital on episode #406 of ABC's Shark Tank.