In the game, players control a squad of four United States Army Special Forces soldiers trapped within a desolated city populated with zombies.

In Harbor City, a United States Army Special Forces fireteam call-signed Raider-3 investigates a government science laboratory that had lost contact with local authorities.

With the materials secured, Vergil aids a surviving pair of United States Marine Corps snipers deployed in the Harbor City Docks in destroying the last remaining cult group led by Malcolm Carter.

The game ends when Vergil makes a decision to deliver the biological sample to Washington, D.C. personally or to stay in Harbor City to protect their family members.

Reviewer Francesco Destri applauded the tactical gameplay and "exciting" dungeon crawling but took issue with the controls and team management of the four-man party.