Romero began her career in 1981 at video game developer and publisher Sir-tech Software, Inc., on the Wizardry role-playing team.

[7] Nerve magazine cited her as a "New Radical" — one of "the 50 artists, actors, authors, activists and icons who are making the world a more stimulating place".

[8] In 2009, Next Generation magazine identified her as the woman with the longest continuous service in video game development.

[citation needed] Brenda Romero was an active member of the International Game Developers Association (IGDA).

[34] Since working on Playboy, she has studied adult and sexual content in video games and is regularly interviewed about the subject in the media.

In the spring of 2007, she was awarded the Presidential Fellowship at Savannah College of Art and Design to develop an exhibit and presentation titled, "What You Don't Know About Video Games...".

According to the series abstract:[38] The Mechanic is the Message captures and expresses difficult experiences through the medium of a game.

"[39] Train was also featured in The Wall Street Journal[40] as well as on game industry sites including Gamasutra, where it received accolades for its ability to evoke meaning through gestures,[41] the Escapist Magazine,[42] Extra Credits,[43] and on Kotaku.

[44] Romero delivered Train: How I Dumped Electricity and Learned to Love Design[45] at the 2010 Gamesauce Conference.

The game features a burlap pillow simulating an earthen mound covered by 26 pieces of grass, each representing a county in Ireland.

In a talk given at the Austin Game Developers Conference in September 2009, Romero noted that the burlap was filled with mementos of her upbringing and her heritage, including photographs of her great grandfather, Paddy Donovan, and one of her mother's rosaries.