Connection to the Milan-Venice high-speed railway (Milan-Verona section) entered operation on 11 December 2016.

Upon completing the entire section, however, some trains might bypass Brescia to run non-stop between Milan and Verona.

Brescia railway station is situated at Viale della Stazione, the south-western edge of the city centre.

Designed by the engineer Benedetto Foix, Brescia station was opened on 24 April 1854 upon the inauguration of the Milan–Venice Railway.

Additional tracks are dedicated to goods trains to and from Brescia Scalo or used for storage of rolling stock.