Brian M. Hoffman (born August 7, 1941 in Chicago) is an American bioinorganic and physical chemist.
Hoffman is a graduate of Lane Tech High School in Chicago and then studied chemistry at the University of Chicago receiving a bachelor's degree in 1962 and at Caltech with a PhD in chemistry in 1966 under the direction of Harden M. McConnell.
Hoffman was briefly a postdoctoral scholar with Alexander Rich at MIT.
Using electron-nuclear double-resonance (ENDOR) spectroscopy, Hoffman has investigated many enzyme mechanisms.
[1] Subject of this work include nitric oxide synthase, cytochrome P450, nickel-iron hydrogenase, and nitrogenase.