Brian Matthews (biochemist)

Brian W. Matthews is a biochemist and biophysicist educated at the University of Adelaide, contributor to x-ray crystallographic methodology[4] at the University of Cambridge, and since 1970 at the University of Oregon as Professor of Physics and HHMI investigator in the Institute of Molecular Biology.

He created hundreds of mutants of T4 lysozyme (making it the most common structure in the PDB), determined their structure by x-ray crystallography and measured their melting temperatures.

Starting from questions about the basis of "temperature-sensitive" mutations,[5] his work has explicated much about the general energetic and structural effects of mutations in proteins.

[6] He also solved early structures of the thermophilic bacterial enzyme thermolysin,[7] the helix-turn-helix DNA-binding transcription factor lambda Cro repressor,[8] and the light-antenna bacteriochlorophyll protein.

[10] The coefficient is used as a measure of the quality of binary (two-class) classifications.