He played college football at Florida and signed with the Atlanta Falcons as an undrafted free agent in 2016.

[8][9][10] Poole received offers from multiple teams, including the Los Angeles Rams, Pittsburgh Steelers, and Arizona Cardinals.

He chose to sign with Atlanta Falcons due to his past relationship with head coach Dan Quinn, who recruited Poole to Florida and was his defensive coordinator there.

[1] Throughout training camp, he competed for a roster spot against DeMarcus Van Dyke, Akeem King, C. J. Goodwin, David Mims, Devonte Johnson, and Jordan Sefon.

[11] He was named the third cornerback on the depth chart, behind Desmond Trufant and Robert Alford, and was also given nickel coverage duties.

[15][16] In the postseason, he played in all three games, starting two, including Super Bowl LI, which the Falcons lost in overtime to the New England Patriots by a score of 34–28.

[21] In week 12 against the Oakland Raiders, Poole recorded an interception off a pass thrown by Derek Carr and returned it for a 15 yard touchdown in the 34–3 win.