Brian Joseph Regan (/ˈriːɡən/) (born June 2, 1958) is an American stand-up comedian who uses observational, sarcastic, and self-deprecating humor.

[3] Regan's material typically covers everyday events, such as shipping a package with UPS, mortgages, and visits to the optometrist.

[4] While he does not define himself as youth-oriented, Regan makes frequent references to childhood, including little league baseball, grade school spelling bees, and science projects.

He has appeared twice on Jerry Seinfeld's show Comedians in Cars Getting Coffee and has released three Netflix comedy specials.

[13] In April 2007, Regan signed a deal with Comedy Central to star in two one-hour stand-up specials, release the specials on DVD, develop a show for the network, and headline a theater tour, Brian Regan in Concert: A Comedy Central Live Event, which began June 8, 2007.

In 2017, Regan was cast as Mugsy in Peter Farrelly's dark comedy series Loudermilk starring Ron Livingston.

[18] That same year, Regan signed a deal with Netflix and Jerry Seinfeld to release two stand-up specials, Nunchucks and Flamethrowers (2017), and Stand Up and Away!

[20] Regan cites Johnny Carson, Steve Martin, George Carlin, Richard Pryor, and David Letterman as influences on his comedy.

Other comedians to have praised Regan include Norm Macdonald, Chris Rock, Jimmy Fallon, Patton Oswalt, David Letterman, and Bill Burr.