He has played a major part in designing a number of multi-million selling games including Civilization II, Rise of Nations, Sid Meier's Alpha Centauri, and FrontierVille.

Reynolds made his first game sale with Quest 1 to SoftSide magazine, its August 1981 cover feature.

[2][3] On June 30, 2009, Zynga announced that Brian Reynolds was leaving Big Huge Games to lead the formation of Zynga East, and serve the role of Chief Game Designer.

"[8] The credits for Alpha Centauri state that the game was "Created by" Brian Reynolds and Meier is listed with several other team members on the "With" line - in the Designers Notes in the game manual Reynolds also thanks him for all his sage advice.

Brian Reynolds' first major break was the design of Sid Meier's Civilization II.

Reynolds and Klaus Teuber collaborated to develop the Xbox Live Arcade game Catan.