He played college football for the Stillman Tigers and was signed by the Jacksonville Jaguars as an undrafted free agent in 2008.

Witherspoon was signed by the Jacksonville Jaguars as an undrafted free agent in 2008.

He tore his ACL for a second straight season during offseason practices with the Giants, and was waived/injured on May 24.

Witherspoon has also played for the Detroit Lions, Carolina Panthers and New York Giants.

In July 2013, Witherspoon retired from football to be a full-time track and field runner.