Brice Prairie is a census-designated place (CDP) in La Crosse County, Wisconsin, United States.

[6] Brice Prairie is located on the east bank of the Mississippi River waterway system.

Brice Prairie borders the Mississippi's Lake Onalaska to the southwest and the Black River to the northwest.

Halfway Creek empties into Lake Onalaska at the southeastern corner of Brice Prairie.

The Upper Mississippi River National Wildlife and Fish Refuge, La Crosse District, borders the CDP to the west and north, and in part to the southeast.

According to the United States Census Bureau, the CDP has a total area of 4.6 square miles (11.9 km2), all of it land.

Brice Prairie holds an outdoor music festival the fourth Saturday in August.