It is located in the heart of the Kennebunk Historic District, occupying 18,000 square feet of space in several buildings on Main Street.

The Brick Store Museum's buildings comprise the oldest commercial block in Kennebunk, with structures dating from 1810 to 1860.

The house at 4 Dane Street (located behind the museum), was built in the 19th century and inherited by Edith Barry through her mother's family.

The decorative and fine arts collections include examples by some of northern New England's finest artists (e.g. Thomas Badger, John Brewster, Jr., Abbott Fuller Graves, William Hackett, Louis D. Norton, and Hannah Brown Skeele).

Regionally significant textiles, clothing, household goods, and maritime artifacts are distinguishing features of the permanent collections.

Additional highlights are the collections pertaining to renowned Maine-based authors Sarah Orne Jewett, Kenneth Roberts, and Booth Tarkington.

Letters, ledgers, corporate records, photographs, glass plate negatives, postcards, charts, architectural plans, maps, and genealogical material are made available to researchers and are used in exhibitions.

[8] The museum underwent comprehensive structural renovations to its four, 19th-century Main Street buildings in 2008–2009, as the result of a capital campaign.