Brindisi railway station is situated at Piazza Francesco Crispi, at the southwest edge of the city centre.

The station was opened on 29 April 1865, during an era of economic expansion, upon the inauguration of the Bari–Brindisi section of the Adriatic Railway.

[2] Nearly nine months later, on 15 January 1866, the Adriatic Railway was extended from Brindisi to Lecce.

[2] Built like a typical transit station, the passenger building had a structure characterized by a sloping flat roof covering the two through tracks and the pedestrian level crossing between platforms.

At Brindisi, the rehabilitation project includes an increase and reorganization of space for passengers with significant improvements in services.