Transmeridian was founded under the name Trans Meridian Flying Service on 5 October 1962 and began operations on 1 November 1962 using a Douglas DC-4.
A second DC-4 (both were ex-military Douglas C-54 Skymaster) was bought and freight services to Dublin and Paris–Le Bourget Airport were begun.
By the end of 1967 the company was taken over by Trans World Leasing and converted into a pure freight operation, with that the name was changed to Transmeridian Air Cargo.
In 1968 the Canadair CL-44 was introduced and eventually eight examples were incorporated the fleet, all being fitted with swinging rear fuselages to facilitate the loading of large items of cargo.
Operations continued throughout the 1970s with 1975 being the year when a base was set up in Hong Kong for freight flights to Australia.