It consists of the district and cadastral territory of Medlánky (German: Medlan), originally an independent municipality that was annexed to Brno in 1919.

This is evidenced by the frequency of finds in the Medlánky brickyard, especially the settlement pit discovered in 1905 with decorated, preserved bell-shaped cups of the culture of the same name (2000 BC) and the burial ground found in 1935–1937 with the graves of typical "squatters" of the Bronze Age - Unetic culture (1900 –1700 BC).

The first preserved written document proving the existence of the village at this time is the charter of King Wenceslaus I from August 14, 1237, by which Medlánky, destroyed by his own war campaign and still belonging to the school of St. Peter in Brno, exchanges for his undamaged property in Bosonohy.

After his death, the childless widow of Jan František Prisca of Magni founded the Marie Školská Foundation (so-called Mariaschul) in 1654 for the education of young noblewomen and middle-class daughters.

It was left with the dilapidated and unused buildings of the former farm with adjacent land, where the reconstruction of the area and new construction is currently underway.

In the second half of the 1960s, during the second cadastral reform of Brno, major changes were made to the boundaries of Medlánky, during which Medlánky lost, among other things, the south-eastern corner with houses on the eastern side of Kuřimská street and the area of the brickyard to Řečkovice, and to Královo Pole the southernmost part, where the university dormitories are located today.

On the contrary, then they acquired forest land in the northeast of Komín or the peripheral northern part of Královo Pole.

As far as urban development is concerned, a large-scale change took place in Medlánky after 1968, when, thanks to the initiative of several young enthusiasts (the Hlaváčová brothers, Ing.

Sedlák, Mrs. Pokorná and others), the Jabloňová housing estate was established here, which is partly located on land originally belonging to Královo Pole.

The city district is home to one of the three Czech SOS children's villages (the others are in Doubí near Karlovy Vary and Chvalčov).

[9][10] Originally a ground-floor building of early Baroque construction used by the Marie Školská Foundation, raised by one floor in the mid-19th century.

The manor's courtyard is a ground-floor baroque building, still in 1935 with beautiful arched window grilles, it was completed in the form known from the photographs in 1765 – 1766.

The belfry on the corner of Kytnerova and Suché streets was undoubtedly built at the same time as the statue of St. John of Nepomuk.

Another inscription on the bell, Anna constantia freyn miniatin, apparently proves that its donor was the Free Lady Konstancie Miniatiová from Campoli, b. Žalkovská from Žalkovice, who in the years 1749–1759 was the director of the Marie Školská Foundation, which was the land lord for Medlánky until 1948.

In 2021, a two-story family house was built in close proximity to the bell tower, thus losing its dominant position.

[12] The memorialists had registered two in Medlánky: an iron one on Kytnerova Street - at the border with the Řečkovice cadastre and a wooden one, later replaced by a stone one, on the way to the airport.

The monument to the resistance and the fallen was built on the 10th anniversary of the creation of Czechoslovakia in 1928 at the initiative of the local Czechoslovak legionary community with the contribution of other Medlánky associations and citizens.