It consists of the cadastral territories of Brno-město (the historic center of the city), Staré Brno, Stránice, Štýřice and Veveří and parts of Černá Pole, Pisárky, Trnitá and Zábrdovice.

But the fire also spread to the monastery of the Franciscans of St. Joseph and finally hit the cathedral of St. Peter and Paul, where he destroyed, among other things, the library and archive.

[2] However, thanks to the hardness and commitment of the defenders and the brilliant organization of the defense by Jean-Louis Raduit de Souches, the Swedes did not succeed and with eight thousand losses they were forced to end the siege.

[citation needed] On July 6, 1850, the territory of Brno was expanded to include 19 other cadastral territories (Dolní a Horní Cejl, Josefov, Kožená, Křenová, Křížová, Malá Nová Ulice, Náhon, Na Hrázi a Příkop, Nové Sady, Pekařská, Silniční, Staré Brno, Špilberk, Švábka, Trnitá, U Svatá Anna, V Jirchářy, Velká Nová Ulice a Červená and Zábrdovice) and its area increased to 17.32 square km; its extended territory (the so-called Inner Brno) roughly overlapped with the modern city district of Brno-střed.

[3] In the years 1859–1864, almost the entire city fortifications of Brno were gradually demolished, of which only short sections, adjacent to the streets of Husova, Bašta, Denisovy Sady and in the courtyard of the Jezuitská 13 house, have been preserved to this day, together with the rebuilt Měnín Gate.

After the demolition, the construction of a new development began in 1864 in its place, and in addition to it, several parks were created in the northeast of the district.

In the years 1898 and 1903, the Old Brno II part of it in connection with the expansion of the cemetery was expanded in the southern direction by other originally Upper Heršpice plots.

The newly acquired, previously outside Brno, lands of the modern district belonged to the cadastres of the following municipalities: Bohunice, Horní Heršpice, Kamenný Mlýn, Komárov and Žabovřesky.

[citation needed] Under communism, fundamental urban changes took place in the area of Brno-střed, which are mostly understood negatively.

The dominant features of the city are the Cathedral of St. Peter and Paul on Petrov hill and Špilberk Castle.

Due to its location within Brno and above all to the fact that it also includes the original historical center of the city, Brno-střed is the most important part of Brno and its administrative, economic and cultural center, where a number of offices and institutions, a number of basic, secondary and universities, many companies and shops.

Among the shops, the Interspar hypermarket on Vídeňská, the multi-storey building of the Tesco department store on Dornych, the Vaňkovka shopping center located between Tesco and the central bus station, as well as the large hobby markets Hornbach and Bauhaus on Heršpická Street are important.

Due to the relocation of people into panel housing estates in the communist era, the population of Brno-střed declined by over half after 1950, only rising again after 2011.