It is managed by Hywel Dda University Health Board.

[1] The hospital has its origins in Aberystwyth Dispensary which was founded in Great Darkgate Street in 1821.

[2] It moved to Upper Portland Street as the Aberystwyth Infirmary and Cardiganshire General Hospital in 1838, to Little Darkgate Street (now called Eastgate) in 1858 and to North Road in 1888.

[2] It joined the National Health Service as Aberystwyth and Cardiganshire General Hospital in 1948.

[5] Local perceptions of under-investment in the hospital led the Welsh Institute for Health and Social Care to conclude in 2014 that there was "a near-dysfunctional level of mistrust, misunderstanding and concern" about the health board's plans.