Brookesia desperata is a species of chameleons.

It is endemic to Foret d'Ambre Special Reserve in north Madagascar, and is a critically endangered species due to the decline of its habitat.

This decline is attributed to clearance of forest for crops, charcoal production, timber extraction, small-scale quarrying and cattle grazing.

[1] It was named desperata to provoke thought regarding the desperately threatened habitat of Madagascar's micro-endemic species.

[2] B. desperata was described in 2012 by a research team led by Dr. Frank Glaw from the Zoologische Staatssammlung München.