It was the second of three frat-house comedy series to air in early 1979 (the others were ABC's Delta House and CBS' Co-Ed Fever).
Chris Lemmon (Milos "Checko" Sabolcik), Jon Cutler (Larry Zipper), and Randy Brooks (Ronald Holmes III) play three students who live in the basement of Pi Nu fraternity, nicknamed "Le Dump".
Rather than attend class, the three cellar-dwellers create havoc with the more strait-laced members of the fraternity, and interact with the Gamma Iota sorority sisters who live nearby.
Two weeks later (February 4), Co-Ed Fever made its debut on CBS after a broadcast of the motion picture Rocky, but all three "frat-house" series were off the air by the end of April (with Co-Ed Fever having only one episode broadcast) after all of them ran into trouble with the networks' Standards and Practices departments because of their content.
Of the three (if CBS' series had been picked up), Brothers and Sisters was arguably the least successful of them (mainly because of the networks having three similar shows, not to mention NBC's own woes at the time), with the show's lack of success apparent when series regular Mary Crosby turned up as a celebrity on NBC's Hollywood Squares for a week in March 1979; host Peter Marshall mentioned Brothers and Sisters as airing "on another network", only to be informed by Crosby that they were, in fact, on the same network.