In 2000, when incumbent State Representative Alzo J. Reddick did not seek re-election, Antone ran to succeed him, facing Gary Siplin, Wardell Sims, Miles Brooks, and David Rucker in the Democratic primary.

He earned the endorsement of the Orlando Sentinel, which praised him as the "best equipped" candidate,[1] but ultimately lost to Siplin and Sims, who advanced to a runoff election, winning 27% of the vote.

Antone emphasized that, unlike Siplin, he would focus on passing bills into law while serving in the legislature and would not waste his time on "feel-good" efforts.

"[4] He emerged successful in the Democratic primary, winning 36% of the vote to Pam Powell's 29%, Sean Bradford's 15%, Rosalind Johnson's 13%, and Jason Henry's 8%.

After defeating incumbent Travaris McCurdy in the August 2022 Democratic primary, Antone won election to the Florida House of Representatives for a third time in 2022.