He is known for his leading roles in the television series How the West Was Won, Bring 'Em Back Alive, Scarecrow and Mrs. King (with Kate Jackson), and Babylon 5 (as John Sheridan in seasons 2–5, 1994–98).

[citation needed] Boxleitner is best known for his leading roles in the television series How the West Was Won, Bring 'Em Back Alive, Scarecrow and Mrs. King (with Kate Jackson and Beverly Garland), and Babylon 5 (as John Sheridan in seasons 2–5, 1994–98).

[4] He also starred in The Gambler (as Billy Montana, alongside Kenny Rogers: 1980, 1983 and 1987) and in such television films as Judith Krantz's Till We Meet Again and Danielle Steel's Zoya.

He was in such made-for-television films as The Secret, Hope Ranch, Falling in Love with the Girl Next Door, Pandemic, Sharpshooter and Aces 'N' Eights.

[6] From 2013 to 2015, he played Bob Beldon, the owner of the local bed and breakfast, in the Hallmark Channel series Cedar Cove.

He gained the role after Brent Spiner stepped down due to a scheduling conflict related to a family matter.

[10] He has also appeared in several films, including Tron (in which he played the title role) and The Baltimore Bullet (1980) with James Coburn.

Other films he has performed in include Kuffs, The Babe, Brilliant, Snakehead Terror, Legion of the Dead, King of the Lost World, Shadows in Paradise and Transmorphers: Fall of Man.

Boxleitner is the author of two science fiction novels with a Western setting, Frontier Earth (1999)[12] and Searcher (2001).

[13] Boxleitner played a major role in the audio dramatization of The Great Secret, part of the Golden Age of Fiction series by L. Ron Hubbard.

[citation needed] Boxleitner's first marriage was to American actress Kathryn Holcomb, who co-starred with him on How The West Was Won as his on-screen sister Laura.